TMC647055-Choline-salt-HCV-Inhibitor-MedChemExpress

发布于:2021-06-18 22:41:12

Inhibitors ? Agonists ? Screening Libraries

TMC647055 Choline salt

Cat. No.: 分?式: 分?量: 作?靶点: 作?通路: 储存?式:

HY-15591A

C??H??N?O?S

727.91

HCV; HCV Protease

Anti-infection; Metabolic Enzyme/Protease

Powder In solvent

-20°C 4°C
-80°C -20°C

3 years 2 years 6 months 1 month

Product Data Sheet

溶解性数据 体外实验

DMSO : ≥ 43 mg/mL (59.07 mM) * "≥" means soluble, but saturation unknown.

制备储备液

Mass Solvent Concentration 1 mM

1 mg 1.3738 mL

5 mM

0.2748 mL

10 mM

0.1374 mL

请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液

5 mg
6.8690 mL 1.3738 mL 0.6869 mL

10 mg
13.7380 mL 2.7476 mL 1.3738 mL

BIOLOGICAL ACTIVITY

?物活性

TMC647055胆碱盐是?种细胞渗透性的, 选择性HCV NS5B抑制剂, 评估病毒RdRp引物依赖性转录测定中, *均IC50为34 nM。

REFERENCES
[1]. Devogelaere B, et al. TMC647055, a potent nonnucleoside hepatitis C virus NS5B polymerase inhibitor with cross-genotypic coverage. Antimicrob Agents Chemother. 2012 Sep;56(9):4676-4684.

McePdfHeight

Caution: Product has not been fully validated for medical applications. For research use only.

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